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Article

Loss of chromosome Y in hematopoietic cells: mechanisms and implications for human disease.

MedScience - 1 Jun 2026

Zhang Siyu, Zhang Zhen, Wang Lan, Qi Meifang

Abstract excerpt

The chromosome Y, once thought to function primarily in male reproduction, is now recognized to have broader biological roles. Hematopoietic loss of chromosome Y (LOY) is one of the most frequent somatic genomic alterations in male blood, with prevalence increasing markedly with age. Advances in technology have enabled robust detection of LOY in blood at both the population scale and the single-cell level....

Read the complete abstract on PubMed

Topics

Humans
Animals
Chromosomes, Human, Y
Male
Hematopoietic Stem Cells
Genome-Wide Association Study
Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Chromosome Deletion

Cardiovascular Diseases

Source

Identifiers

PMID: 42418133
DOI: 10.1007/s11684-026-1246-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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