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Article

Loss of Y in leukocytes as a risk factor for critical COVID-19 in men

13 Dec 2022

Abstract excerpt

BACKGROUND: The COVID-19 pandemic, which has a prominent social and economic impact worldwide, shows a largely unexplained male bias for the severity and mortality of the disease. Loss of chromosome Y (LOY) is a risk factor candidate in COVID-19 due to its prior association with many chronic age-related diseases, and its impact on immune gene transcription. METHODS: Publicly available scRNA-seq data of PBMC...

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PMID: 36514076
DOI: 10.1186/s13073-022-01144-5

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