Article
Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer.
Nature genetics - 1 Jun 2014
Forsberg Lars A, Rasi Chiara, Malmqvist Niklas, Davies Hanna, Pasupulati Saichand, Pakalapati Geeta, Sandgren Johanna, Diaz de Ståhl Teresita, Zaghlool Ammar, Giedraitis Vilmantas, Lannfelt Lars, Score Joannah, Cross Nicholas C P, Absher Devin, Janson Eva Tiensuu, Lindgren Cecilia M, Morris Andrew P, Ingelsson Erik, Lind Lars, Dumanski Jan P
Abstract excerpt
Incidence and mortality for sex-unspecific cancers are higher among men, a fact that is largely unexplained. Furthermore, age-related loss of chromosome Y (LOY) is frequent in normal hematopoietic cells, but the phenotypic consequences of LOY have been elusive. From analysis of 1,153 elderly men, we report that LOY in peripheral blood was associated with risks of all-cause mortality (hazards ratio (HR) = 1.91,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.