Circulating macrophages as the mechanistic link between mosaic loss of Y-chromosome and cardiac disease

Abstract excerpt

BACKGROUND: Genetics evidences have long linked mosaic loss of Y-chromosome (mLOY) in peripheral leukocytes with a wide range of male age-associated diseases. However, a lack of cellular and molecular mechanistic explanations for this link has limited further investigation into the relationship between mLOY and male age-related disease. Excitingly, Sano et al. have provided the first piece of evidence directly...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Eosinophilic Disorders and Syndromes
• Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
• Share to Genetic Associations and Epidemiology