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Loss of chromosome Y in regulatory T cells

5 Mar 2024

Abstract excerpt

BACKGROUND: Mosaic loss of chromosome Y (LOY) in leukocytes is the most prevalent somatic aneuploidy in aging humans. Men with LOY have increased risks of all-cause mortality and the major causes of death, including many forms of cancer. It has been suggested that the association between LOY and disease risk depends on what type of leukocyte is affected with Y loss, with prostate cancer patients showing higher...

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PMID: 38443832
DOI: 10.1186/s12864-024-10168-7

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