Article

Spermidine suppresses glial inflammation and parkinsonian abnormalities in ATP13A2 deficiency

2026-06-04

Abstract excerpt

Pathogenic variants in ATP13A2 , which encodes an endolysosomal polyamine exporter, cause Kufor-Rakeb syndrome and are associated with early-onset parkinsonism and related neurodegenerative disorders; however, the mechanisms by which ATP13A2 dysfunction drives disease remain incompletely defined. In Atp13a2 knockout mice, we identified an early, transient reduction in brain polyamines that precedes overt gliosis...

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Literature Corpus work: 8c96147c-47d4-52e2-971f-e514ac63182f
DOI: 10.64898/2026.05.23.26353575

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