Article
ATP13A2 Regulates Cellular α-Synuclein Multimerization, Membrane Association, and Externalization.
International journal of molecular sciences - 7 Mar 2021
Si Jianmin, Van den Haute Chris, Lobbestael Evy, Martin Shaun, van Veen Sarah, Vangheluwe Peter, Baekelandt Veerle
Abstract excerpt
ATP13A2, a late endo-/lysosomal polyamine transporter, is implicated in a variety of neurodegenerative diseases, including Parkinson's disease and Kufor-Rakeb syndrome, an early-onset atypical form of parkinsonism. Loss-of-function mutations in ATP13A2 result in lysosomal deficiency as a consequence of impaired lysosomal export of the polyamines spermine/spermidine. Furthermore, accumulating evidence suggests the...
Topics
- Cell Line, Tumor
- Exocytosis
- Humans
- Intracellular Membranes
- Lysosomes
- Mutation
- Oxidative Stress
- Proteasome Endopeptidase Complex
- Protein Multimerization
- Proton-Translocating ATPases