Article
ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.
Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 2020
Vrijsen Stephanie, Besora-Casals Laura, van Veen Sarah, Zielich Jeffrey, Van den Haute Chris, Hamouda Norin Nabil, Fischer Christian, Ghesquière Bart, Tournev Ivailo, Agostinis Patrizia, Baekelandt Veerle, Eggermont Jan, Lambie Eric, Martin Shaun, Vangheluwe Peter
Abstract excerpt
Recessive loss-of-function mutations in ATP13A2 (PARK9) are associated with a spectrum of neurodegenerative disorders, including Parkinson's disease (PD). We recently revealed that the late endo-lysosomal transporter ATP13A2 pumps polyamines like spermine into the cytosol, whereas ATP13A2 dysfunction causes lysosomal polyamine accumulation and rupture. Here, we investigate how ATP13A2 provides protection against...
Topics
- Activating Transcription Factor 4
- Adenosine Triphosphatases
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Eflornithine
- Fibroblasts
- Lysosomes
- Mitochondria