Article

Reduction of Spermine Synthase Suppresses Tau Accumulation Through Autophagy Modulation in Tauopathy

2023-03-19

Abstract excerpt

<h4>ABSTRACT</h4> Tauopathy, including Alzheimer Disease (AD), is characterized by Tau protein accumulation and autophagy dysregulation. Emerging evidence connects polyamine metabolism with the autophagy pathway, however the role of polyamines in Tauopathy remains unclear. In the present study we investigated the role of spermine synthase (SMS) in autophagy regulation and tau protein processing in Drosophila and...

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Literature Corpus work: 909b29c5-a400-53c4-955e-042bf1847f47
DOI: 10.1101/2023.03.17.533015

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