Article

Metabolic reprogramming and altered ATP content impair neuroprotective functions of microglia in β-glucocerebrosidase deficiency models

2025-05-29

Abstract excerpt

Mutations in the GBA gene, which reduce β-glucocerebrosidase (GCase) activity, represent the most significant genetic risk factor for Parkinson’s disease (PD). Decreased GCase activity has also been observed in sporadic PD cases, supporting a broader role for GCase in the poorly understood mechanisms underlying PD etiopathogenesis. While most studies on the relationship between GBA mutations and PD have focused...

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Literature Corpus work: 7fdefa2d-b436-584e-bd10-52b77a56ea4a
DOI: 10.1101/2025.05.26.656111

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