Article
ATP13A2 restrains macrophage NLRP3 inflammasome activation to repress neurodegeneration via modulating mitochondrial homeostasis.
Proceedings of the National Academy of Sciences of the United States of America - 24 Mar 2026
Zou Ziqi, Zhou Jiajie, Lu Yanhua, Huang Yuting, Zhou Linru, Wang Xiaoyu, Chen Jiahui, Tian Hengrui, Ge Xinnuo, Guo Chenyao, Yao Weiran, Zheng Xiaosheng, He Jia, Du Yue, Zhou Yiting, Song Yinjing, Luo Wei, Wang Qingqing, Liu Jun-Ping, Xia Meng
Abstract excerpt
Neuro-immune crosstalk is increasingly recognized in Parkinson's disease (PD), and ATP13A2 is well known for its neuroprotective role. However, it remains unclear whether ATP13A2 mutations carried by PD patients contribute to immune dysfunction that exacerbates disease progression. Here, we systematically demonstrate that many ATP13A2 mutations result in a loss-of-expression phenotype. ATP13A2 is highly expressed...
Topics
- NLR Family, Pyrin Domain-Containing 3 Protein
- Animals
- Humans
- Macrophages
- Inflammasomes
- Mitochondria
- Mice
- Parkinson Disease
- Homeostasis