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Article

ATP13A2 deficiency disrupts lysosomal polyamine export.

Nature - 1 Feb 2020

van Veen Sarah, Martin Shaun, Van den Haute Chris, Benoy Veronick, Lyons Joseph, Vanhoutte Roeland, Kahler Jan Pascal, Decuypere Jean-Paul, Gelders Géraldine, Lambie Eric, Zielich Jeffrey, Swinnen Johannes V, Annaert Wim, Agostinis Patrizia, Ghesquière Bart, Verhelst Steven, Baekelandt Veerle, Eggermont Jan, Vangheluwe Peter

Abstract excerpt

ATP13A2 (PARK9) is a late endolysosomal transporter that is genetically implicated in a spectrum of neurodegenerative disorders, including Kufor-Rakeb syndrome-a parkinsonism with dementia1-and early-onset Parkinson's disease2. ATP13A2 offers protection against genetic and environmental risk factors of Parkinson's disease, whereas loss of ATP13A2 compromises lysosomes3. However, the transport function of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 31996848
DOI: 10.1038/s41586-020-1968-7

Genes

ATP13A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ATP13A2 deficiency disrupts lysosomal polyamine export.PMID 31996848Read ↗

ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.Semantic proximity Read ↗

ATP13A2 Regulates Cellular α-Synuclein Multimerization, Membrane Association, and Externalization.Semantic proximity Read ↗

Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegenerationSemantic proximity Read ↗

Functional characterization of ATP13A2 variants associated with distinct neurodegenerative disordersSemantic proximity Read ↗

Structural basis of polyamine transport by human ATP13A2 (PARK9)Semantic proximity Read ↗

ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons.Semantic proximity Read ↗

Lysosomal dysfunction in Parkinson diseaseSemantic proximity Read ↗

ATP13A2/PARK9 regulates endo-/lysosomal cargo sorting and proteostasis through a novel PI(3, 5)P2-mediated scaffolding function.Semantic proximity Read ↗

Structural mechanisms for gating and ion selectivity of the human polyamine transporter ATP13A2.Semantic proximity Read ↗

Spermidine suppresses glial inflammation and parkinsonian abnormalities in ATP13A2 deficiencySemantic proximity Read ↗

Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicitySemantic proximity Read ↗

Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity.Semantic proximity Read ↗

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