Article

The autophagy activator Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model

2021-10-29

Abstract excerpt

Deposition of amyloid beta (Aβ) along with glia cell-mediated neuroinflammation are prominent pathogenic hallmarks of Alzheimer’s disease (AD). In recent years, impairment of autophagy has been found to be another important feature, contributing to AD progression and aging. Therefore, we assessed the effect of the autophagy activator Spermidine, a small body-endogenous polyamine often used as dietary supplement an...

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Literature Corpus work: fd7ccddf-4305-5ed2-a201-c4992c1fd4a5
DOI: 10.1101/2021.10.28.466219

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