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Placental treatment with <i>insulin-like growth factor 1</i> via nanoparticle differentially impacts vascular remodeling factors in guinea pig sub-placenta/decidua

2022-09-27

Abstract excerpt

Clinically, fetal growth restriction (FGR) is only detectable in later gestation, despite pathophysiological establishment likely earlier in pregnancy. Additionally, there are no effective in utero treatment options for FGR. We have developed a nanoparticle to deliver human insulin-like 1 growth factor ( hIGF-1 ) in a trophoblast-specific manner which results in increased expression of hIGF-1 . IGF-1 signaling...

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Literature Corpus work
8c90ed78-b781-513e-acf1-2c16d9f7d51d
DOI
10.1101/2022.09.26.509492
Open publication

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Placental treatment with <i>insulin-like growth factor 1</i> via nanoparticle differentially impacts vascular remodeling factors in guinea pig sub-placenta/deciduaDOI 10.1101/2022.09.26.509492
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