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Insulin-like growth factor 1 signaling in the placenta requires endothelial nitric oxide synthase to support trophoblast function and normal fetal growth

2020-08-23

Abstract excerpt

Currently, there is no effective treatment for placenta dysfunction in utero . In a ligated mouse model of fetal growth restriction (FGR), nanoparticle-mediated human insulin-like 1 growth factor ( hIGF1 ) gene delivery (NP-Plac1-hIGF1) increased hIGF1 expression and maintained fetal growth. However, whether it can restore fetal growth remains to be determined. Using the endothelial nitric oxide synthase knock...

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Literature Corpus work
65f6b758-e1ab-50eb-9a12-06de1060f3d4
DOI
10.1101/2020.08.21.261420
Open publication

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Insulin-like growth factor 1 signaling in the placenta requires endothelial nitric oxide synthase to support trophoblast function and normal fetal growthDOI 10.1101/2020.08.21.261420
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