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Placental nanoparticle gene therapy normalizes gene expression changes in the fetal liver associated with fetal growth restriction in a fetal sex-specific manner

2022-09-27

Abstract excerpt

Fetal growth restriction (FGR) is associated with increased risk of developing Non-Communicable Diseases. We have a placenta-specific nanoparticle gene therapy protocol that increases placental expression of human insulin-like growth factor 1 ( hIGF-1 ), for the treatment of FGR in utero . We aimed to characterize the effects of FGR on hepatic gluconeogenesis pathways during early stages of FGR establishment, a...

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Literature Corpus work
2873d98f-20cd-5fe9-afac-81bfbd8604b9
DOI
10.1101/2022.09.26.509494
Open publication

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Placental nanoparticle gene therapy normalizes gene expression changes in the fetal liver associated with fetal growth restriction in a fetal sex-specific mannerDOI 10.1101/2022.09.26.509494
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