Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insulin-like growth factor 1 signaling in the placenta requires endothelial nitric oxide synthase to support trophoblast function and normal fetal growth

23 Feb 2021

Abstract excerpt

Currently, there is no effective treatment for placental dysfunction in utero. In a ligated mouse model of fetal growth restriction (FGR), nanoparticle-mediated human insulin-like 1 growth factor ( hIGF1) gene delivery (NP-Plac1-hIGF1) increased hIGF1 expression and maintained fetal growth. However, whether it can restore fetal growth remains to be determined. Using the endothelial nitric oxide synthase knockout...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birth, Development, and Health
Share to Gestational Diabetes Research and Management
Share to Pregnancy and preeclampsia studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33621475
DOI: 10.1152/ajpregu.00250.2020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insulin-like growth factor 1 signaling in the placenta requires endothelial nitric oxide synthase to support trophoblast function and normal fetal growthPMID 33621475Read ↗

Insulin-like growth factor 1 signaling in the placenta requires endothelial nitric oxide synthase to support trophoblast function and normal fetal growthSemantic proximity Read ↗

Placental treatment with <i>insulin-like growth factor 1</i> via nanoparticle differentially impacts vascular remodeling factors in guinea pig sub-placenta/deciduaSemantic proximity Read ↗

Maternal-fetal interfaces transcriptome changes associated with placental insufficiency and a novel gene therapy interventionSemantic proximity Read ↗

Mid-pregnancy placental transcriptome in a model of placental insufficiency with and without novel interventionSemantic proximity Read ↗

Placenta <i>hIGF1</i> nanoparticle treatment in guinea pigs mitigates fetal sex dependent FGR-associated effects on kidney structure and blood pressure-related signaling pathwaysSemantic proximity Read ↗

Mechanistic insights into the development of severe fetal growth restrictionSemantic proximity Read ↗

Correction of Preeclampsia by Intraplacental Gene Transfer of IGF-1 in the BPH/5 Mouse via NF-KB Mediated Induction of Angiogenic Gene ExpressionSemantic proximity Read ↗

Placental nanoparticle gene therapy normalizes gene expression changes in the fetal liver associated with fetal growth restriction in a fetal sex-specific mannerSemantic proximity Read ↗

Placental <i>hIGF1</i> nanoparticle gene therapy in guinea pigs ameliorates fetal growth restriction-associated changes in hepatic lipid and glucose metabolism-related signaling pathways in a fetal sex-specific mannerSemantic proximity Read ↗

A human cytotrophoblast-villous endothelium-fetal organ multi-cell model and the impact on gene and protein expression in placenta cytotrophoblast, fetal hepatocytes and fetal kidney epithelial cellsSemantic proximity Read ↗

Early Abnormal Placentation and Evidence of Vascular Endothelial Growth Factor System Dysregulation at the Feto-Maternal Interface After Periconceptional Alcohol ConsumptionSemantic proximity Read ↗

Trophoblast-Specific Expression of Hif-1α Results in Preeclampsia-Like Symptoms and Fetal Growth RestrictionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.