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Maternal, placental and fetal response to a non-viral, polymeric nanoparticle gene therapy in nonhuman primates

2023-06-19

Abstract excerpt

<h4>Background</h4> Currently, there are no placenta-targeted treatments to alter the in utero environment. Water-soluble polymers have a distinguished record of clinical relevance outside of pregnancy. We have demonstrated the effective delivery of polymer-based nanoparticles containing a non-viral human insulin-like 1 growth factor ( IGF1 ) transgene to correct placental insufficiency in small animal models...

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Literature Corpus work
2421a2fe-8462-5044-be6b-d79ea0a498a9
DOI
10.1101/2023.06.16.545278
Open publication

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Maternal, placental and fetal response to a non-viral, polymeric nanoparticle gene therapy in nonhuman primatesDOI 10.1101/2023.06.16.545278
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