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Placental <i>hIGF1</i> nanoparticle gene therapy in guinea pigs ameliorates fetal growth restriction-associated changes in hepatic lipid and glucose metabolism-related signaling pathways in a fetal sex-specific manner

2024-11-03

Abstract excerpt

<h4>ABSTRACT</h4> Fetal development in an adverse in utero environment significantly increases the risk of developing metabolic diseases in later life, including dyslipidemia, non-alcoholic fatty liver diseases and diabetes. The aim of this study was to determine whether improving the in utero fetal growth environment with a placental nanoparticle gene therapy would ameliorate fetal growth restriction (FGR)-assoc...

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Literature Corpus work
70db7e4c-4e37-5a42-83c6-fa64893444e2
DOI
10.1101/2024.10.30.621100
Open publication

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Placental <i>hIGF1</i> nanoparticle gene therapy in guinea pigs ameliorates fetal growth restriction-associated changes in hepatic lipid and glucose metabolism-related signaling pathways in a fetal sex-specific mannerDOI 10.1101/2024.10.30.621100
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