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Nanoparticle-mediated transgene expression of <i>insulin-like growth factor 1</i> in the growth restricted guinea pig placenta increases placenta nutrient transporter expression and fetal glucose concentrations

2021-06-25

Abstract excerpt

Fetal growth restriction (FGR) significantly contributes to neonatal and perinatal morbidity and mortality. Currently, there are no effective treatment options for FGR during pregnancy. We have developed a nanoparticle gene therapy targeting the placenta to increase expression of human insulin-like growth factor 1 ( hIGF-1 ) to correct fetal growth trajectories. Using the maternal nutrient restriction (MNR) guin...

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Literature Corpus work
8102193a-d240-5247-bb0a-d9f35d4ecf51
DOI
10.1101/2021.06.24.449769
Open publication

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Nanoparticle-mediated transgene expression of <i>insulin-like growth factor 1</i> in the growth restricted guinea pig placenta increases placenta nutrient transporter expression and fetal glucose concentrationsDOI 10.1101/2021.06.24.449769
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