Article

Islet amyloid disrupts MHC Class II antigen presentation and protects NOD mice from autoimmune diabetes

2024-09-14

Abstract excerpt

Islet amyloid contributes to beta cell failure in type 2 diabetes through several mechanisms, one being the potent induction of local islet inflammation through activating inflammatory pathways in islet macrophages. We performed an unbiased phenotypic investigation of islet macrophages in the early stage of islet amyloid formation using single cell RNA sequencing of resident islet macrophages in mice with and with...

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Literature Corpus work: 8c896bef-2ff1-583e-8eb2-9f27a8dd0482
DOI: 10.1101/2024.09.10.612362

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