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Article

Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes.

The Journal of experimental medicine - 1 Jun 2020

Zakharov Pavel N, Hu Hao, Wan Xiaoxiao, Unanue Emil R

Abstract excerpt

Tissue-specific autoimmune diseases are driven by activation of diverse immune cells in the target organs. However, the molecular signatures of immune cell populations over time in an autoimmune process remain poorly defined. Using single-cell RNA sequencing, we performed an unbiased examination of diverse islet-infiltrating cells during autoimmune diabetes in the nonobese diabetic mouse. The data revealed a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32251514
DOI: 10.1084/jem.20192362
PMCID: PMC7971127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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