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Article

Islet amyloid formation is an important determinant for inducing islet inflammation in high-fat-fed human IAPP transgenic mice.

Diabetologia - 1 Sept 2014

Meier Daniel T, Morcos Mary, Samarasekera Thanya, Zraika Sakeneh, Hull Rebecca L, Kahn Steven E

Abstract excerpt

AIMS/HYPOTHESIS: Amyloid deposition and inflammation are characteristic of islet pathology in type 2 diabetes. The aim of this study was to determine whether islet amyloid formation is required for the development of islet inflammation in vivo. METHODS: Human islet amyloid polypeptide transgenic mice and non-transgenic littermates (the latter incapable of forming islet amyloid) were fed a low-fat (10%) or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24965964
DOI: 10.1007/s00125-014-3304-y
PMCID: PMC4267509

Genes

IAPP
NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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