Article

SAP loss limits anti-insulin atypical B cell activation and pro-inflammatory CD8 T cells despite preserved Tfh responses to protect against type 1 diabetes

2026-08-02

Abstract excerpt

SLAM-associated protein (SAP) is required for T follicular helper (Tfh)-B cell interactions that underlie germinal center formation, but it is unclear if SAP governs islet-reactive CD4+ T cell-B cell interactions and downstream pro-inflammatory CD8+ T cell destruction of islets in type 1 diabetes (T1D). To address this question, we utilized the VH125 SD .NOD mouse model, whereby 1-3% of all B cells bind insulin....

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Literature Corpus work: 7e49e8d3-4ee3-5945-bddf-a8af3467dcce
DOI: 10.64898/2026.07.29.741363

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