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Article

Understanding autoimmune diabetes: insights from mouse models.

Trends in molecular medicine - 1 Jan 2002

Adorini Luciano, Gregori Silvia, Harrison Leonard C

Abstract excerpt

Type 1 or insulin-dependent diabetes is an autoimmune disease that causes the selective destruction of insulin-secreting beta cells in the pancreatic islets. Although this is a polygenic disease, with at least 20 genes implicated, the dominant susceptibility locus maps to the major histocompatibility complex (MHC), both in humans and in rodent models. However, in spite of progress on several fronts, the molecular...

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PMID: 11796264
DOI: 10.1016/s1471-4914(01)02193-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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