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Article

Arteriovenous malformation Map2k1 mutation affects vasculogenesis.

Scientific reports - 8 Jul 2023

Sudduth Christopher L, Smits Patrick J, Vivero Matthew P, Cheng Yu Sheng, Ad Michal, Konczyk Dennis J, Bischoff Joyce, Warman Matthew L, Greene Arin K

Abstract excerpt

Somatic activating MAP2K1 mutations in endothelial cells (ECs) cause extracranial arteriovenous malformation (AVM). We previously reported the generation of a mouse line allowing inducible expression of constitutively active MAP2K1 (p.K57N) from the Rosa locus (R26GT-Map2k1-GFP/+) and showed, using Tg-Cdh5CreER, that EC expression of mutant MAP2K1 is sufficient for the development of vascular malformations in the...

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Identifiers

PMID: 37422456
DOI: 10.1038/s41598-023-35301-6
PMCID: PMC10329712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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