Article
A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos.
Developmental biology - 1 Jul 2007
Jin Suk-Won, Herzog Wiebke, Santoro Massimo M, Mitchell Tracy S, Frantsve Julie, Jungblut Benno, Beis Dimitris, Scott Ian C, D'Amico Leonard A, Ober Elke A, Verkade Heather, Field Holly A, Chi Neil C, Wehman Ann M, Baier Herwig, Stainier Didier Y R
Abstract excerpt
Formation of a functional vasculature during mammalian development is essential for embryonic survival. In addition, imbalance in blood vessel growth contributes to the pathogenesis of numerous disorders. Most of our understanding of vascular development and blood vessel growth comes from investigating the Vegf signaling pathway as well as the recent observation that molecules involved in axon guidance also...
Topics
- Animals
- Blood Vessels
- Embryo, Nonmammalian
- Endothelial Cells
- Genomics
- Mutagenesis
- Mutation
- Neovascularization, Physiologic
- Transgenes
- Vertebrates
- Zebrafish