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Endothelial cells require functional FLVCR1a during developmental and adult angiogenesis

11 Jan 2023

Abstract excerpt

The Feline Leukemia Virus Subgroup C Receptor 1a (FLVCR1a) is a transmembrane heme exporter essential for embryonic vascular development. However, the exact role of FLVCR1a during blood vessel development remains largely undefined. Here, we show that FLVCR1a is highly expressed in angiogenic endothelial cells (ECs) compared to quiescent ECs. Consistently, ECs lacking FLVCR1a give rise to structurally and...

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PMID: 36631598
DOI: 10.1007/s10456-023-09865-w

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