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Article

Angiopoietin-1 is essential in mouse vasculature during development and in response to injury

23 May 2011

Abstract excerpt

Angiopoietin-1/Tek signaling is a critical regulator of blood vessel development, with conventional knockout of angiopoietin-1 or Tek in mice being embryonically lethal due to vascular defects. In addition, angiopoietin-1 is thought to be required for the stability of mature vessels. Using a Cre-Lox conditional gene targeting approach, we have studied the role of angiopoietin-1 in embryonic and adult vasculature....

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PMID: 21606590
DOI: 10.1172/jci46322

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