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Article

Zebrafish Kelch-like family member 4 is required for vasculogenesis and hematopoiesis.

Developmental biology - 1 Sept 2025

Ferrari Kaitlin, Gurung Suman, Loges Luiza N, Batta Surya Prakash Rao, Hammond Myles A, Griciunaite Martyna, DeMoya Ricardo, Restrepo Nicole K, Sumanas Saulius

Abstract excerpt

Molecular mechanisms regulating vascular development and hematopoiesis are still incompletely understood. The KLHL (Kelch-like) family of proteins function as adapters to target proteins for ubiquitination. However, their role in vascular development has not been previously analyzed. Here we have characterized a novel regulator of vascular development, kelch-like family member 4 (klhl4) in zebrafish. We show that...

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Identifiers

PMID: 40404079
DOI: 10.1016/j.ydbio.2025.05.018
PMCID: PMC12256021

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