Article

Machine Learning Discoveries of TOP2A-X Synergy in ETC-1922159 Treated Colorectal Cancer Cells

2025-01-09

Abstract excerpt

DNA topoisomerase II α (TOP2A) belongs to the family of topoisomerases, which regulates the (un)winding of the DNA due to its double helical structure. The main function of TOP2A is to relieve the topological stress during DNA transcription, assist in separation of chromatids and condensation of chromosomes. In colorectal cancer (CRC) cells treated with ETC-1922159, TOP2A was found to be down regulated along with...

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Literature Corpus work: 68dc1a70-3c01-5c6e-9157-d0afbd7e0108
DOI: 10.20944/preprints202501.0687.v1

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