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Article

HMGA2 expression defines a subset of human AML with immature transcriptional signature and vulnerability to G2/M inhibition

7 Jul 2022

Abstract excerpt

High-mobility group AT-hook 2 (HMGA2) is a nonhistone chromatin-binding protein that is normally expressed in stem cells of various tissues and aberrantly detected in several tumor types. We recently observed that one-fourth of human acute myeloid leukemia (AML) specimens express HMGA2, which associates with a very poor prognosis. We present results indicating that HMGA2+ AMLs share a distinct transcriptional...

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PMID: 35797243
DOI: 10.1182/bloodadvances.2021005828

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