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TOPII-targeting and MUS81 deficiency sensitise HER2-low tumour models to T-DXd

2026-08-06

Abstract excerpt

<h4>ABSTRACT</h4> In this study, we identify Topoisomerase II α (TopII α) targeting and MUS81 deficiency as sensitisers to trastuzumab deruxtecan (T-DXd), a HER2-targeting antibody–drug conjugate with a potent topoisomerase I poison payload that is of clinical importance in the treatment of HER2 expressing solid tumours in a range of cancer types. Using preclinical tumour spheroid models of breast and colorectal...

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Literature Corpus work
f2880e28-ac21-54b3-add4-a9de22314963
DOI
10.64898/2026.08.04.742772
Open publication

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TOPII-targeting and MUS81 deficiency sensitise HER2-low tumour models to T-DXdDOI 10.64898/2026.08.04.742772
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