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Article

Genome Instability Induced by Topoisomerase Misfunction.

International journal of molecular sciences - 24 Sept 2024

Nitiss Karin C, Bandak Afif, Berger James M, Nitiss John L

Abstract excerpt

Topoisomerases alter DNA topology by making transient DNA strand breaks (DSBs) in DNA. The DNA cleavage reaction mechanism includes the formation of a reversible protein/DNA complex that allows rapid resealing of the transient break. This mechanism allows changes in DNA topology with minimal risks of persistent DNA damage. Nonetheless, small molecules, alternate DNA structures, or mutations in topoisomerase...

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Source

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Identifiers

PMID: 39408578
DOI: 10.3390/ijms251910247
PMCID: PMC11477040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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