Article

The logic of native enhancer-promoter compatibility and cell-type-specific gene expression variation

2022-07-19

Abstract excerpt

Cis-regulatory enhancers are essential for differential expression of developmental and housekeeping genes. However, the specificity of native mammalian enhancers and how it shapes cell-type-specific gene expression landscapes remain largely unknown. We show that endogenous enhancers are broadly compatible with the promoters of developmental and housekeeping genes. Broad enhancer compatibility affords ‘retrofittin...

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Literature Corpus work: 8c41c7bf-4322-5b7c-8c19-a8de9b517763
DOI: 10.1101/2022.07.18.500456

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