Article

Smallpox-specific T cells in vaccinated centenarians exhibit different phenotypic and metabolic traits of long-term memory compared to SARS-CoV-2-specific memory T cells.

2026-02-10

Abstract excerpt

<title>Abstract</title> Long-term T cell memory is essential for durable protection against infectious diseases, yet the cellular and molecular programs that sustain antigen-specific immunity for decades in humans remain incompletely understood. Here, we combine high-dimensional single-cell approaches to dissect CD4⁺ and CD8⁺ T cell memory elicited by a remote childhood vaccination (vaccinia/smallpox) and a re...

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Literature Corpus work: 8c38db7d-5539-5433-a21a-e42140dd13a6
DOI: 10.21203/rs.3.rs-8805423/v1

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