Article

Single-cell transcriptomics reveals expansion of cytotoxic CD4 T-cells in supercentenarians

2019-05-20

Abstract excerpt

Supercentenarians, people who have reached 110 years of age, are a great model of healthy aging. Their characteristics of delayed onset of age-related diseases and compression of morbidity imply that their immune system remains functional. Here we performed single-cell transcriptome analysis of 61,202 peripheral blood mononuclear cells (PBMCs), derived from seven supercentenarians and five younger controls. We ide...

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Literature Corpus work: 377508ea-bebe-555b-b4d2-155eec8c3bb1
DOI: 10.1101/643528

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