Article

Dissecting the heterogeneity of DENV vaccine-elicited cellular immunity using single-cell RNA sequencing and cellular metabolic profiling

2019-01-03

Abstract excerpt

<h4>ABSTRACT</h4> Generating effective and durable T cell immunity is a critical prerequisite for vaccination against dengue virus (DENV) and other viral diseases. Understanding the precise molecular mechanisms of vaccine-elicited T cell immunity remains a critical knowledge gap in vaccinology. In this study, we utilized single-cell RNA sequencing (scRNAseq) and TCR clonotype analysis to demonstrate that a unique...

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Literature Corpus work: 375afc67-cd30-5e52-9983-9db89fc40cea
DOI: 10.1101/511428

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