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Why Some People Live Past 100: The Role of the Immune System in Centenarians, Semi-Supercentenarians and Supercentenarians

2026-08-25

Abstract excerpt

Centenarians, semi-supercentenarians and supercentenarians (i.e. oldest centenarians) display complex and heterogeneous immune remodelling. In this setting, immune at-trition, memory, cytotoxic defence, inflammatory regulation and tissue surveillance remain sufficiently balanced to support survival with relatively preserved health. This review examines these processes within an integrated framework encompassing se...

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Literature Corpus work: ffcc7a00-136e-5af7-8c02-0408cdb4674a
DOI: 10.20944/preprints202608.1820.v1

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