Article

Serial vaccination expands and refines human CD4 <sup>+</sup> T cell memory

2026-04-13

Abstract excerpt

CD4 + T cells coordinate protective immunity against pathogens. However, a major unresolved question is how human CD4 + T cell memory is established and evolves following primary and repeated vaccination. Using COVID-19 mRNA vaccination as a model, we tracked 50 distinct antigen-specific populations directly ex vivo with peptide–MHC class II tetramers in eight SARS-CoV-2–naïve individuals from pre-vaccine baseli...

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Literature Corpus work: e5f8b271-f4ca-532c-b5ff-2d532a2eb10a
DOI: 10.64898/2026.04.11.716570

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