Article

Functional Characterization of Cooperating MGA Mutations in RUNX1::RUNX1T1 Acute Myeloid Leukemia

2023-09-22

Abstract excerpt

<title>Abstract</title> <p>MGA (Max-gene associated) is a dual-specificity transcription factor that negatively regulates MYC-target genes to inhibit proliferation and promote differentiation. Loss-of-function mutations in <italic>MGA</italic> have been commonly identified in several hematological neoplasms, including acute myeloid leukemia (AML) with <italic>RUNX1::RUNX1T1</italic>, however, very little is known...

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Literature Corpus work: 8bee2050-4520-53b3-8a93-58cf5b54c943
DOI: 10.21203/rs.3.rs-3315059/v1

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