Article

Therapeutic Targeting of the Menin–KMT2A Interaction

2024-01-02

Abstract excerpt

The direct targeting of chromatin-associated proteins is increasingly recognized as a potential therapeutic strategy for the treatment of cancer. In this review, we discuss a prominent example, namely, small-molecule inhibitors that target the menin–KMT2A interaction. These molecules are currently being investigated in clinical trials and showing significant promise. We describe the unique specificity of menin–KMT...

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Literature Corpus work: 65483065-2c5b-5c36-b674-98282cde1ff5
DOI: 10.1146/annurev-cancerbio-062822-021934

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