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Article

Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2017

Simon Laura, Lavallée Vincent-Philippe, Bordeleau Marie-Eve, Krosl Jana, Baccelli Irène, Boucher Geneviève, Lehnertz Bernhard, Chagraoui Jalila, MacRae Tara, Ruel Réjean, Chantigny Yves, Lemieux Sébastien, Marinier Anne, Hébert Josée, Sauvageau Guy

Abstract excerpt

Purpose:RUNX1-mutated (RUNX1mut) acute myeloid leukemia (AML) is associated with adverse outcome, highlighting the urgent need for a better genetic characterization of this AML subgroup and for the design of efficient therapeutic strategies for this disease. Toward this goal, we further dissected the mutational spectrum and gene expression profile of RUNX1mut AML and correlated these results to drug sensitivity...

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Share to Cell Line, Tumor
Share to Core Binding Factor Alpha 2 Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

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Share to Gene Expression Regulation, Leukemic

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Share to Glucocorticoids

Share to Leukemia, Myeloid, Acute

Source

Identifiers

PMID: 28855357
DOI: 10.1158/1078-0432.CCR-17-1259

Genes

RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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