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Article

Addiction of t(8;21) and inv(16) Acute Myeloid Leukemia to Native RUNX1

1 Sept 2013

Abstract excerpt

The t(8;21) and inv(16) chromosomal aberrations generate the oncoproteins AML1-ETO (A-E) and CBFβ-SMMHC (C-S). The role of these oncoproteins in acute myeloid leukemia (AML) etiology has been well studied. Conversely, the function of native RUNX1 in promoting A-E- and C-S-mediated leukemias has remained elusive. We show that wild-type RUNX1 is required for the survival of t(8;21)-Kasumi-1 and inv(16)-ME-1...

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Identifiers

PMID: 24055056
DOI: 10.1016/j.celrep.2013.08.020

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