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Article

Functional characterization of cooperating MGA mutations in RUNX1::RUNX1T1 acute myeloid leukemia.

Leukemia - 1 May 2024

Thomas Melvin E, Qi Wenqing, Walsh Michael P, Ma Jing, Westover Tamara, Abdelhamed Sherif, Ezzell Lauren J, Rolle Chandra, Xiong Emily, Rosikiewicz Wojciech, Xu Beisi, Loughran Allister J, Pruett-Miller Shondra M, Janke Laura J, Klco Jeffery M

Abstract excerpt

MGA (Max-gene associated) is a dual-specificity transcription factor that negatively regulates MYC-target genes to inhibit proliferation and promote differentiation. Loss-of-function mutations in MGA have been commonly identified in several hematological neoplasms, including acute myeloid leukemia (AML) with RUNX1::RUNX1T1, however, very little is known about the impact of these MGA alterations on normal...

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Topics

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Share to Basic Helix-Loop-Helix Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 2 Subunit

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Myeloid, Acute

Share to Oncogene Proteins, Fusion

Share to Proto-Oncogene Proteins

Share to RUNX1 Translocation Partner 1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 38454121
DOI: 10.1038/s41375-024-02193-y
PMCID: PMC11073986

Genes

MGA
RUNX1
RUNX1T1
MYC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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