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Article

Integrative analysis of RUNX1 downstream pathways and target genes.

BMC genomics - 31 Jul 2008

Michaud Joëlle, Simpson Ken M, Escher Robert, Buchet-Poyau Karine, Beissbarth Tim, Carmichael Catherine, Ritchie Matthew E, Schütz Frédéric, Cannon Ping, Liu Marjorie, Shen Xiaofeng, Ito Yoshiaki, Raskind Wendy H, Horwitz Marshall S, Osato Motomi, Turner David R, Speed Terence P, Kavallaris Maria, Smyth Gordon K, Scott Hamish S

Abstract excerpt

BACKGROUND: The RUNX1 transcription factor gene is frequently mutated in sporadic myeloid and lymphoid leukemia through translocation, point mutation or amplification. It is also responsible for a familial platelet disorder with predisposition to acute myeloid leukemia (FPD-AML). The disruption of the largely unknown biological pathways controlled by RUNX1 is likely to be responsible for the development of...

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Identifiers

PMID: 18671852
DOI: 10.1186/1471-2164-9-363
PMCID: PMC2529319

Genes

RUNX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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