Article
Multi-Omics Analysis Identifies MGA as a Negative Regulator of the MYC Pathway in Lung Adenocarcinoma.
Molecular cancer research : MCR - 1 Apr 2020
Llabata Paula, Mitsuishi Yoichiro, Choi Peter S, Cai Diana, Francis Joshua M, Torres-Diz Manuel, Udeshi Namrata D, Golomb Lior, Wu Zhong, Zhou Jin, Svinkina Tanya, Aguilera-Jimenez Estrella, Liu Yanli, Carr Steven A, Sanchez-Cespedes Montse, Meyerson Matthew, Zhang Xiaoyang
Abstract excerpt
Genomic analysis of lung adenocarcinomas has revealed that the MGA gene, which encodes a heterodimeric partner of the MYC-interacting protein MAX, is significantly mutated or deleted in lung adenocarcinomas. Most of the mutations are loss of function for MGA, suggesting that MGA may act as a tumor suppressor. Here, we characterize both the molecular and cellular role of MGA in lung adenocarcinomas and illustrate...
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