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Article

RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity.

Blood cancer journal - 8 Jan 2016

Chin D W L, Sakurai M, Nah G S S, Du L, Jacob B, Yokomizo T, Matsumura T, Suda T, Huang G, Fu X-Y, Ito Y, Nakajima H, Osato M

Abstract excerpt

RUNX1/AML1 is among the most commonly mutated genes in human leukemia. Haploinsufficiency of RUNX1 causes familial platelet disorder with predisposition to myeloid malignancies (FPD/MM). However, the molecular mechanism of FPD/MM remains unknown. Here we show that murine Runx1(+/-) hematopoietic cells are hypersensitive to granulocyte colony-stimulating factor (G-CSF), leading to enhanced expansion and...

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Share to Blood Platelet Disorders
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 2 Subunit

Share to Gene Expression Regulation, Leukemic

Share to Granulocyte Colony-Stimulating Factor

Share to Haploinsufficiency

Share to Receptors, CXCR4

Share to STAT3 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 26745853
DOI: 10.1038/bcj.2015.105
PMCID: PMC4742622

Genes

RUNX1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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