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Article

Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity.

Genes & development - 1 Mar 2008

Zhao Xinyang, Jankovic Vladimir, Gural Alexander, Huang Gang, Pardanani Animesh, Menendez Silvia, Zhang Jin, Dunne Richard, Xiao Andrew, Erdjument-Bromage Hediye, Allis C David, Tempst Paul, Nimer Stephen D

Abstract excerpt

RUNX1/AML1 is required for the development of definitive hematopoiesis, and its activity is altered by mutations, deletions, and chromosome translocations in human acute leukemia. RUNX1 function can be regulated by post-translational modifications and protein-protein interactions. We show that RU...

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Share to Antigens, CD34
Share to Arginine
Share to Core Binding Factor Alpha 2 Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoiesis

Share to Methylation

Share to Protein-Arginine N-Methyltransferases

Share to RNA, Small Interfering

Share to RUNX1 Translocation Partner 1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 18316480
DOI: 10.1101/gad.1632608
PMCID: PMC2259033

Genes

RUNX1
PRMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18316480-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity.PMID 18316480Read ↗

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