Article

<i>RUNX1</i> isoform disequilibrium in the development of trisomy 21 associated myeloid leukemia

2022-03-08

Abstract excerpt

Aneuploidy is a hallmark of cancer, but its complex nature limits our understanding of how it drives oncogenesis. Gain of chromosome 21 (Hsa21) is among the most frequent aneuploidies in leukemia and is associated with markedly increased leukemia risk. Here, we propose that disequilibrium of the RUNX1 isoforms is key to the pathogenesis of trisomy 21 (i.e. Down syndrome)-associated myeloid leukemia (ML-DS). Hsa21...

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Literature Corpus work: c6882aea-32df-5ec8-9274-26836f3c0f14
DOI: 10.1101/2022.03.07.483334

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